why is tirzepatide being discontinued Results — Weight Loss Timeline & What to Expect A Major GLP-1 Drug Shortage

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When switching from semaglutide to tirzepatide, some people report increased energy due to tirzepatide additional GIP receptor effects, which may improve nutrient absorption and metabolic efficiency

However, some patients report muscle tightness, aches, or cramping during real-world use

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The SURMOUNT-1 body composition substudy confirmed that roughly 75% of weight lost on tirzepatide was fat mass, with visceral fat (the metabolically dangerous kind around organs) falling by 40.1%