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Notably, Linagliptin is primarily excreted via the enterohepatic system, with less than 1% eliminated unchanged in the urine

However, once the animal model is established, it is necessary to select indicators to judge and evaluate whether the plateau animal model is successful given that it is impossible to quantify the symptoms of animals based on human standards

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investigated the dose-dependent hepatotoxic effects of subcutaneously injected EGCG (55, 70, and 125 mg/kg/day) in mice (229)