In the CY 2026 OPPS/ASC proposed rule, we proposed to apply this submission method to PRO-PMs generally, including the Information Transfer PRO-PM (90 FR 33782)
They found a half-life of under 30 minutes post-injection, with bioavailability after intramuscular administration at 14 to 19 percent for rats and 45 to 51 percent for dogs
And it exposes something most testing simply doesnt capture: Purity does not equal performance in solution Three Vials, One Problem In the example above from Jan 2025 ( when I was still in Swiss) BAC (bacteriostatic water) cloudy Filtered water mostly clear Saline particles still visible Same vial
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BAC water, or bacteriostatic water, is sterile water containing 0.9% benzyl alcohol as a preservative
H19 expression downregulates telomerase enzyme activity by binding to and disrupting the hTERT- hTR interaction
