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In this form of polyneuropathy, the first nerve fibers to malfunction are those most distant from the central nervous system, with symptoms such as pain and numbness felt symmetrically in the feet, and then traveling up the legs as the condition progresses

(PubMed) Sano M, Ernesto C, Thomas RG, et al

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FIGURE 5 The primary source of ROS in the endoplasmic reticulum is the formation of intramolecular disulfide bonds during the maturation of many secreted proteins and membrane proteins