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A medical consultation is important before starting treatment, especially for anyone with a history of pancreatitis, gallbladder disease, severe gastrointestinal disease, certain endocrine cancers, pregnancy, breastfeeding, complex diabetes medication use, or a personal or family history of medullary thyroid carcinoma or MEN2

*Correspondence: Jing Liu, [email protected]

But interest is growing in their effects beyond metabolismparticularly their potential influence on the brain and risk of dementia

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These effects may be unique to low doses of naltrexone and appear to be entirely independent from naltrexones better-known activity on opioid receptors

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