For glycemic control, these medications typically reduce HbA1c by 1.0-2.0% in patients with type 2 diabetes
The American Diabetes Association now recommends GLP-1 RAs for patients with established ASCVD regardless of their A1C and regardless of if the patient is taking metformin, the historically first line medication for T2DM [38]
Weeks 34: 2 mg once weekly (Increase only if early GI symptoms are mild and stable) Weeks 58 : 4 mg once weekly Weeks 912: 8 mg once weekly Week 13+: 12 mg once weekly (Only escalate to higher doses if indicated and previous doses were well tolerated) Balanced schedule: Standard trial-inspired ramp This schedule follows a typical balanced titration pace similar to what many clinical trials use
J Clin Endocrinol Metab 37(5):826828 Elahi D, Andersen DK, Brown JC et al (1979) Pancreatic alpha-and beta-cell responses to GIP infusion in normal man
Zheng et al showed that GLP-1 RA use was associated with a lower risk of DR in 2,390 patients in a national Swedish registry using both observational and genetic data
Dehydration can also make headaches and dizziness worse
