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The suggestion is that reduced GR activity and therefore less 'reduced glutathione' may be implicated in Irritable Bowel Syndrome - possibly because it has less defenses against free radicals, the cause of oxidative stress

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& Langenberg, P

Immune Resilience Immune cells rely on glutathione to regulate inflammation and mount precise, effective responses

Second, patients with chronic kidney disease (CKD) stages 3b through 5 may have impaired copper excretion through bile and urine [13]