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For instance, experiments involving high-iron diets or the depletion of Gpx4 , which induces ferroptosis, promote pancreatitis and pancreatic tumorigenesis in mice [209, 210]

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Interestingly, several recent publications have indicated the implicated role of necroptosis in CP-mediated ototoxicity (Choi et al., 2019

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Mechanistically, drugs such as mecamylamine act as noncompetitive antagonists at neuronal nicotinic acetylcholine receptors, producing a poretrapping block by entering and becoming trapped within the open ion channel (second panel)

F., de Souza, A