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Peptides like [Kisspeptin-10]( for example, are researched for their ability to directly stimulate the hypothalamus to release GnRH

doi: 10.1111/j.1476-5381.2010.00834.x

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In elderly human subjects, studies on epithalamin (the parent extract) showed that individuals with low baseline melatonin experienced a meaningful restoration of nighttime melatonin levels following treatment, while those with normal function showed no overshoot

After the same treatment, the mean fluorescence intensity was measured using a FACS Calibur flow cytometer (Becton-Dickinson, San Jose, USA)