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Additionally, NADH can be generated by fatty acid oxidation (FAO) in the cytoplasm in tissues with high energy demand, such as cardiac muscle tissues, as well as in cancer cells 141

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Schizophrenia For decades ago, there was a report of MTHFR enzymatic activity reduction in two schizophrenia patients which were 18 and 21% percent of the normal level, respectively, while homocysteine remethylation was also defected 42

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Wang W, Uzzau S, Goldblum SE, Fasano A

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