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Early signals may appear first: appetite, satiety, nausea, bowel-pattern changes, and scale movement can show up before the formal trial endpoints, especially during dose escalation

Freezing should be avoided, as extreme temperatures can adversely affect medication stability

Recent studies have demonstrated that histone lactylation plays a critical role in fibrosis progression by promoting histone lactylation at the promoters of profibrotic genes

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Study populations, inclusion criteria, trial duration, comparator design, and development-stage context all limit how broadly findings can be interpreted