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Pediatric Patients: Dosing is weight-based (10-20 mg/kg), similar to adults, but requires careful monitoring of growth and metabolic markers

This can boost insurance coverage likelihood, ensuring compliance with approved uses, particularly for those in Detroit

doi: 10.1038/s41591-023-02672-2 137 De GiorgiRKoychevIAdlerAICowenPJHarmerCJHarrisonPJet al

Drugs with very high volumes of distribution have much higher concentrations in extravascular tissue than in the vascular compartment, ie, they are not homogeneously distributed

Careful Administration (Use with Caution) 12.1 Patients with Renal Impairment Renal impairment necessitates cautious use

Additionally, nitrites may participate in direct nitration reactions that modify thiol groups and amines in bacterial proteins, further compromising cellular function 15