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doi 10.1016/j.eclinm.2021.100979 103 ColwillMPovlsenSPollokRPatelKGoodhandJAhmadTet al
Unlike the situation in the POMC-null mice, humans with a lack of POMC expression are unable to survive without glucocorticoid supplementation from birth
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It was found that the overlapped DEGs were dominantly enriched in long-chain fatty acid metabolic process, steroid hydroxylase activity, steroid hydroxylase activity, monooxygenase activity, heme binding, epoxygenase P450 pathway, tetrapyrrole binding, arachidonic acid epoxygenase activity, cellular lipid metabolic process, lipid metabolic process, arachidonic acid monooxygenase activity, fatty acid metabolic process, etc
Individuals in the placebo group lost, on average, just 2.4% of their body weight compared to baseline
