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This is particularly relevant for patients with familial adenomatous polyposis who face a high risk of small-intestinal tumours 4
Demirci A, Hzl F, Hamurcu HD, Baar H
Its half-life is short (7 minutes) because it is rapidly cleaved by dipeptidyl peptidase-IV (DPP-IV) after residues 2-3
Its supporting evidence is animal and cell-culture research, some of it genuinely interesting (systemic anti-inflammatory and gene-expression effects have been studied in mice), but animal injection data doesn't establish human injectable dosing, safety, or efficacy any more than any other animal study does
Both RickA and Sca2 contribute to cell-to-cell spread, however Sca2-based motility is the major mediator of cell-to-cell spread 34,35,36,37,64