In contrast to GIPRs, GLP-1Rs are not expressed in adipose tissue (170)
Health Beyond the Scale Maintaining weight loss is not only about appearance
GLP-1 medications (semaglutide/Wegovy, tirzepatide/Zepbound) have become incredibly popular for women dealing with midlife weight gain
Note : Oral options are compounded, meaning theyre custom-formulated by a pharmacy and not FDA-approved
Much literature to date has focused on the risk for drug-induced acute pancreatitis attributed to hyperstimulation of acinar cells 14,15
Notably, the extent of weight loss achieved with GLP-1 RA therapy may be directly linked to the degree of reduction in preference for high-calorie foods as semaglutide was associated with reduced cravings for both savory and sugary foods, with decreases in craving scores correlating with greater weight loss (Blundell et al., 2017