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Evidence (sorafenib): A phase III, randomized, double-blind, placebo-controlled study (DECISION [NCT00984282]) evaluated sorafenib in patients with progressive, iodine-refractory, differentiated thyroid cancer.[21] This trial included 417 patients with locally advanced or metastatic RAI-refractory thyroid cancer (papillary, follicular [including Hrthle cell], and poorly differentiated tumors) whose disease had progressed within the past 14 months

Overall, these findings suggest an absence of measurable publication bias or small-study effects

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