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When it is finally released, its availability must be more strictly controlled than semaglutide to avoid similar life-threatening usage. Dr Marie Spreckley, of the MRC epidemiology unit at the University of Cambridge, said: Higher discontinuation due to adverse events, particularly gastrointestinal symptoms, is a key consideration and may have implications for tolerability and adherence in real-world settings. She added that because the trial lasted only one year, longer-term safety, cardiovascular outcomes and sustained effectiveness remained important unanswered questions