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It is also used as an antidote to cyanide poisoning

Effect of study bias, publication bias, and small-study effects In all analyses, the pooled estimated SMDs for the subgroups of studies deemed to have low bias was within the 95% CI of the overall (Table 4), suggesting the impact of studies with higher bias was small

Proponents recommend doing coffee enemas 1x-2x/day for 4-8 weeks before shifting to one maintenance enema every 2 months

Wang X, Liu X, Gong F, Jiang Y, Zhang C, Zhou W

Berberine Berberine, a natural compound found in plants like European barberry, Phellodendron, tree turmeric, and Oregon grape, is known to improve insulin sensitivity and lower blood sugar