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It has been proposed that hyperpigmentation in the epidermal basal layer as well as the presence of dermal melanophages may be due to faulty transfer of melanosomes from melanocytes to keratinocytes, resulting in a lack of melanosomes in keratinocytes in the upper epidermis and pigment incontinence in the dermis

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The study also revealed a statistically significant drop in IOP after starting GLP-1 receptor agonist treatment, especially in those with a history of glaucoma or pre-existing excessive IOP. The researchers also found that GLP-1 agonist use in the management of type 2 diabetes may have possible cardiovascular advantages

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