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DS-8500a, an orally available G protein-coupled receptor 119 agonist, upregulates glucagon-like peptide-1 and enhances glucose-dependent insulin secretion and improves glucose homeostasis in type 2 diabetic rats

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Besides the 10 thermostabilizing mutations that reported previously 26,27 , E387 7.42b D was introduced to mimic the identified interaction in the GCGR-NNC1702 complex structure 9

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So getting three faces right was incredibly difficult' (Molteni, Chen)