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This drug leads to an increase in Actinobacteria and Firmicutes phyla along with a decrease in Bacteroidetes

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H&E staining results further confirmed that the aortic wall thickness of mice treated with FOXO4-DRI was significantly thinner, and ultrasound examination results showed that the PWV of the aorta was slowed down after FOXO4-DRI treatment, indicating better vascular elasticity and significantly improved vascular function compared to the control group (Figures 2D,E)

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Below is a table to compare the side effect profiles: Personal experience goes a long way in how individuals deal with these side effects