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Trials conducted between 2001 and 2007 demonstrated statistically significant reductions in body fat, although the larger Phase IIb OPTIONS trial did not replicate these findings at sufficient magnitude for regulatory approval, and formal development was discontinued in 2007

[6] [7] Injectable supplements are not included in these pathways

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While the liver was previously thought to be the main target of metformins glucose-lowering effects, recent evidence suggests that other parts of the body, such as the gastrointestinal tract, also play a role in its overall clinical advantages

Lau DCW, Erichsen L, Francisco AM, Satylganova A, le Roux CW, McGowan B, et al

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