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The World Health Organization estimates it affects up to 30% of non-pregnant women, 37% of pregnant women, and up to 40% of children

Rose et al 2023 demonstrated that certain chemotherapeutic drugs such as talazoparib, camptothecin and etoposide binds and traps proteins (PARP and topoisomerases I and II, respectively) on DNA strands, resulting in DNA damage and double-strand breaks

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High levels of ROS resets circadian clocks and induces a range of prosurvival responses and different expression of clock genes secondarily to a pro-inflammatory environment, such as activation of cAMP/CREB signaling

It is supported by this hypothesized mechanism by one longitudinal clinical cohort study: serum ROS levels were associated with joint space narrowing and its 5-year progression

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