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"Iodine deficiency activates antioxidant genes and causes DNA damage in the thyroid gland of rats and mice." Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1773(6): 990999

Moreover, proteases originating from gut bacteria could have a role in the gut barrier function, probably via damage to the gut mucus layer and junction proteins

Adv Bioscience Biotechnol

It is also worth mentioning that many CKD studies that apply microbiota intervention report that patients show very minimal to no side effects to their use

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These refer to the action of the heart, where systolic is the contracted, pumping blood pressure, and diastolic is the relaxed blood pressure