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By increasing Akkermansia and Bifidobacterium populations through resistant starch feeding, and by supporting gut barrier integrity through postbiotics, the supplement aims to create a gut environment that consistently produces more GLP-1 in response to meals

N Engl J Med (2024);390(13):11761185

A 2026 review in the New England Journal of Medicine noted that questions about long-term dosing and durability of results remain open areas of research, not settled strategy

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