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The relationship between the AGE-RAGE system and infertility was also documented: AGEs have a negative effects on the reproductive outcome in women undergoing ART (assisted reproduction technology), AGE high levels in NON PCOS women appear to be related to the decrease in ovarian reserve and abnormal folliculogenesis

10.1016/j.aquatox.2006.07.008 60 ThompsonJ

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The skin protective barrier can be compromised by environmental conditions, which in turn enhances antigen penetration and immune system activation