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The contraindication list is extensive
For most people, the bigger practical factors are: how quickly weight is coming off whether protein intake is adequate whether resistance training is happening consistently whether strength and body composition are being tracked with more than the scale Who This Matters For This article matters most for: people deciding between semaglutide and tirzepatide people already using one of these drugs and worrying about muscle loss adults over 40 who care about strength, function, and frailty risk readers who want a better body-composition result, not just a lower scale number Key Takeaways both semaglutide and tirzepatide can be associated with some lean-mass loss during weight loss current evidence does not justify a blanket claim that one is always harder on muscle tirzepatide may outperform semaglutide on fat-mass reduction in some comparisons, but its effect on fat-free mass remains uncertain the higher-quality question is not just which drug causes more loss, but how do I protect lean mass while losing fat resistance training, protein, and rate of loss still matter more than medication brand name alone What the Evidence Says The strongest practical conclusion is cautious, not absolute
However, the website claims the low-calorie diet plan includes 1,300 to 1,500 nutritionally dense calories from whole, affordable foods like eggs, poultry, fish, meats, fruits, vegetables, whole grains including potatoes and bread (with minimal ingredients), and healthy fats like olive oil. Heres a list of what you can eat on the GOLO diet, broken down by the programs food categories
Consistent sleep schedules, cool bedroom temperatures, and avoiding screens 12 hours before bed optimize rest quality, helping your body recover from metabolic adjustment stress
Common side effects may include temporary flushing, nausea, or headache
