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When patients taking tirzepatide report vaginal spotting, clinicians should systematically evaluate alternative explanations, as the medication itself is not known to cause gynecological bleeding

The underlying mucosa, conjunctiva, and tympanic membranes may be also be pigmented and may darken with age

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It says most cases resolve within four to eight weeks, and that providers may recommend bile acid sequestrants or dietary soluble fiber to manage symptoms

2022 Feb;179(4):62541