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Pujol, J., Blanco-Hinojo, L., Martnez-Vilavella, G., Deus, J., Prez-Sola, V., & Sunyer, J

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Dehydration : Manifests as decreased urination, dark urine, dry mouth, dizziness upon standing, and fatigue Cardiovascular symptoms may occur, particularly as secondary effects of dehydration or anxiety: Increased heart rate (tachycardia) Palpitations or irregular heartbeat Lightheadedness or fainting Potential signs of pancreatitis (a rare but serious adverse effect): Severe, persistent abdominal pain, often radiating to the back Pain that worsens after eating Nausea and vomiting that doesn't resolve Tenderness when touching the abdomen Other potential symptoms include: Severe fatigue or weakness Headache Visual disturbances (if hypoglycemia develops) Altered mental status or confusion Symptom onset may begin within hours of injection but often intensifies over 1-2 days, aligning with tirzepatide's pharmacokinetic profile (peak concentration at approximately 24-48 hours)

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