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NICE Clinical Knowledge Summaries and British Society for Haematology guidelines support B12 supplementation in these clinical contexts, with treatment regimens tailored to the underlying cause

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& Martin-Verstraete, I

Springer-Verlag, Berlin,New York

This internal clock helps our body know when it's time to be awake and when it's time to rest

Injury and inflammation to the pigmented layer of the retina (retinal pigment epithelium or RPE) as well as the choroid cause an altered and abnormal diffusion of nutrients to the retina and RPE, possibly precipitating further RPE and retinal damage (Zarbin 2004)