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When cyp2e1 knockout mice that lack the ability to produce the CYP2E1 enzyme were challenged with acetaminophen, they were found to be considerably less sensitive to its hepatotoxic effects than wild-type animals, indicating that this CYP is the principal enzyme responsible for the metabolic conversion of the drug acetaminophen to its active hepatotoxic metabolite NAPQI (Figure 2)

Die verwendeten Rohstoffe werden sorgfltig ausgewhlt und geprft, um eine gleichbleibend hohe Produktqualitt sicherzustellen

J Cardiovasc Pharmacol Ther 11(2):105112 Bilal R, Zakaria M, Usman A, Zia A (2011) Comparison of simvastatin with Eugenia jambolana fruit pulp in their effects on alanine transferase, aspartate aminotransferase and creatinine phosphokinase levels of hyperlipidaemic rats

Song, X.-R., Goswami, N., Yang, H.-H

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