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Receptor activation can be maintained for the duration of the experiment without dosing complexity

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As in the pilot study, patients taking methotrexate therapy at baseline were allowed to remain on this drug during the trial, and approximately 40% of the patients in both arms did so, at a mean dose of about 16 mg per week

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Inactivation of these enzymes correlated with increased hydrogen peroxide, decreased ATP level, accumulation of lipid peroxides such as malondialdehyde (MDAL), and triglyceride fat accumulation, respectively [44]

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