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PPAR2 is primarily expressed in adipose tissue and promotes the differentiation and proliferation of adipocytes, which are derived from fibroblasts, resulting in an increase in adiposity [26]
Patients entered a run-in treatment period on glimepiride (4 mg per day) alone or glimepiride in combination with metformin HCl (1500 mg per day)
Ozempic is administered as a once-weekly subcutaneous injection , typically into the abdomen, thigh, or upper arm
The SELECT trial demonstrated a 20% reduction in major cardiovascular events
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