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Tirzepatide's dual GLP-1 and GIP receptor activation creates stronger appetite suppression and better insulin control, leading to greater results for many patients

The safety profile of oral semaglutide in these trials was similar to that expected of other GLP-1RAs, with tolerability issues mainly comprising mostly transient, mild-to-moderate gastrointestinal events [7,8,9,10,11]

Tandogan B, Ulusu NN

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This dual action creates a powerful reduction in the drive to eat, allowing you to consume smaller portions without the constant preoccupation with food that often accompanies traditional dieting

Whether GLP-1RAs exert direct modulation of the hypothalamic-pituitary-ovarian (HPO) axis beyond these metabolic pathways remains to be verified by clinical mechanistic evidence