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However, higher concentrations of kynurenine and its metabolites, such as quinolinic acid may increase the frequency and intensity of seizures, and dysregulation of the KP has been linked to the pathophysiology of epilepsy

Thus, liver damage is quite sensitive to polymorphisms in the glucoronosyl transferases and this probably explains some of the variation in patient response

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The cost per measurable result, however, often favors the stack because the clinical effects are larger and more reliable

Elements and evolution