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In contrast, MSNs in the indirect pathway or the striatopallidal pathway inhibit downstream thalamocortical targets and activation of this pathway may suppress certain behaviors (Graybiel, 2000)
A negative feedback mechanism involving the hypothalamus, pituitary gland, and thyroid gland regulates thyroid hormones secretion as follows: The hypothalamus secretes TRH (thyrotropin-releasing hormone), which stimulates TSH (thyroid-stimulating hormone) release from the pituitary gland
Studies have demonstrated that GLP-1 receptor activation may reduce production of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-), interleukin-6 (IL-6), and interleukin-1 beta (IL-1) the same inflammatory mediators that drive joint destruction in rheumatoid arthritis
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