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[8] Similarly, patients with gout or hyperuricemia should avoid high niacin intake, as niacin (even in nicotinamide form) can raise uric acid levels and potentially trigger gout flares

Sharma AM, Birney S, Crotty M, et al

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While the rare risk of medullary thyroid cancer requires a cautious approach for those with a specific family history, these medications offer a potentially transformative path for many who have struggled with weight for years