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Rather than viewing ED solely as a vascular issue, emerging evidence highlights a complex neural-endocrine network with untapped therapeutic potential

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Nevertheless, under physiological conditions, in most tissues mitochondria are the major contributors to the cellular ROS production [28,29,30,31], mainly as a side effect of aerobic respiration via oxidative phosphorylation (OXPHOS) occurring on the inner membrane of the mitochondrion [32, 33], but also through other metabolic routes, such as pentose-phosphate pathway and glutathione (GSH) metabolism [34]

However, it is worth noting that Ozempic also demonstrated a higher incidence of side effects