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44.Aroda VR, Saugstrup T, Buse JB, Donsmark M, Zacho J, Davies MJ

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Multiple physiological mechanisms contribute to weight loss plateaus during tirzepatide therapy, reflecting the body's sophisticated homeostatic responses to caloric restriction and weight reduction

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Research from the STEP programme (semaglutide), SCALE studies (liraglutide), and SURMOUNT trials (tirzepatide) consistently demonstrates significant reductions in waist circumference, which correlates with abdominal fat loss