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First study in humans showing that ACC inhibition (with ND-630/GS-0976) reduces liver DNL

Electrophysiological and c-Fos mapping studies in rodent models have demonstrated that amylin receptor activation in these regions inhibits gastric emptying, reduces meal size, and activates downstream satiety circuits projecting to the hypothalamic arcuate nucleus (Lutz et al., Physiology & Behavior, 2010)

For this measure, REHs are required to report on an annual basis the number of patients who screen positive for one or more of the five SDOH domains divided by the total number of patients screened (reported as five separate rates)

10.1016/j.cell.2005.05.007 193

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