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At the 12-month follow-up : 87.5% of patients reported significant relief defined as 50% reduction in baseline pain scores Mean VAS pain score dropped from 7.2 at baseline to 2.8 at 12 months KOOS (Knee Injury and Osteoarthritis Outcome Score) improved across all subscales: pain, symptoms, activities of daily living, sport/recreation, and quality of life No serious adverse events were reported across the treatment period The durability of the response at 12 months is particularly notable

The advantage is especially beneficial to men who have to deal with rigorous work routines, physical activities, and everyday tasks

JCI Insight 7 , e157694 (2022)

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The compound's procognitive effects stem from its ability to enhance synaptogenesisthe formation of new functional synapses between neuronsparticularly in the hippocampus, a brain region essential for learning and memory consolidation