retatrutide phase 2 nejm weight loss 48 weeks 2023 percent Retatrutide (not yet approved in US but people using anyway) promises even potentially greater weight loss amongst the GLP1 drugs. https://www.nejm .org/doi/full/10.1056/NEJMoa2301972 GLP-1 Medications for Weight Loss:

[Perkovic FLOW, NEJM 2024] STEP 1 Extension (Discontinuation Data) After stopping semaglutide, participants regained approximately two-thirds of lost weight within one year

Phase 3 trials are the key stage for FDA approval

Intriguingly, in our studies, hypothalamic CAMK2 expression was upregulated by GLP1/E

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Its hard to know if retatrutide has more side effects [compared with other obesity drugs] until you do studies comparing the medications head-to-head, Jay says

Pregnant patients or those planning conception within six months are also excluded