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Weight loss is a relatively new use for these medications, and they may have limitations and side effects that research has not yet identified

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Vellas, D

A review published in the British Journal of Clinical Pharmacology found that while caffeine can slightly increase metabolic rate, the effects on long-term weight loss are minimal unless combined with diet and exercise

Additionally, weight loss itself lowers your daily calorie burn, meaning the same food intake that produced initial weight loss may now simply maintain your current weight

Water-soluble vitamins like vitamin C and the B vitamins aren't stored long-term