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At the level of thyroid hormone synthesis, TNF- can directly inhibit the activity of thyroid peroxidase (TPO), and IL-1 stimulates iodothyronine 5-deiodine activity in the liver to affect the metabolism of thyroid hormone (Fujii et al., 1989)

Nat Rev Endocrinol 15(5):288298 Lobstein T, Jackson-Leach R, Powis J, Brinsden H, Gray M (2023) World obesity atlas 2023

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Many people find these injections especially useful for targeting stubborn areas of stored fat, making it easier to reach their fitness and health goals