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PMID 15327888

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Activates FAK (Focal Adhesion Kinase) and paxillin to strengthen cellular adhesion and biomechanics

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The disturbance of endoplasmic reticulum Ca2+ triggered by oxidative stress may also induce UPR and apoptosis ( + T cells to produce adaptive immune response, and T cells release interferon- (INF-), It binds to receptors on keratinocytes, further releases and presents inflammatory cytokines such as CXC-L16 and IL-15, and further recruits T cells to the skin through a positive feedback loop ( + and T cells induced by cytokines and chemokines ensure the final destruction of epidermal melanocytes (Figure 1)

The April 15, 2026 removal from Category 2 was procedural