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Early-stage studies revealed an initial increase in 24 h ambulatory SBP, which subsided over time, leading to a net reduction in SBP
doi 10.1056/NEJMoa2032183 / Saxena AR, Frias JP, Brown LS, et al
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Notwithstanding, TIR alleviated memory impairment in STZ-induced diabetic rats by modulating insulin resistance and the inflammatory response through restoration of the PI3K/Akt/GSK-3 signaling pathway (Guo et al., 2023)
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