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Glutathione transferases and neurodegenerative diseases

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Benedetto J-P, Ortonne J-P, Voulot C, Khatchadourian C, Prota G, Thivolet J

Our results demonstrated that AsGGT1, AsGGT2, and AsGGT3 actively deglutamylate -glutamyl- S -allyl-L-cysteine, whereas these GGTs have almost no deglutamylation activity toward -glutamyl- S -allyl-L-cysteine sulfoxide ( Figure 4

This knowledge now opens novel ways to improve interventions that could combat age-related muscle atrophy and impaired regeneration with fibrosis and fat infiltration (including sarcopenia and frailty)

This method enhances its ability to clear airways, neutralize toxins, and fight oxidative stress at a cellular level