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14,15 Once released into the circulation, GH binds and activates the cell-surface GHR, as well as the related prolactin receptor in target tissues such as liver, muscle, bone, and adipose tissue (Fig

A structured diagnostic approach, including clinical evaluation, differential diagnosis, and assessment of therapeutic response when appropriate, is essential to avoid misdiagnosis in elderly patients with cirrhosis, as the response to HE treatment may help confirm the diagnosis (Fig

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