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Slow-Titration Protocol: Conservative Escalation for Nausea-Prone Users The Phase 2 trial protocol explicitly allowed prescribers to delay or skip dose escalation at physician discretion for participants who did not tolerate the protocol-specified increase (Jastreboff et al., NEJM 2023, Supplementary Appendix)

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Alcohol and Smoking Both alcohol consumption and smoking are major "glutathione thieves." They create a high demand for detoxification in the liver and lungs, which can quickly drain your antioxidant stores

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