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Neither approach is inherently better

(2022b, December 8)

26 Manganese Similar to copper and zinc, manganese is an essential component of a superoxide dismutase enzyme (MnSOD) which reduces oxidative stress in cells

Inhibition of the system xc GSHGPX4 axis can predispose cells to ferroptosis, while the primary initiation of ferroptosis typically occurs through the accumulation of toxic lipids, as discussed later in the section

(1991): Psychological stress increases dopamine turnover selectively in mesoprefrontal dopamine neurons in rats: reversal by diazepam

But that doesn't mean it's appropriate for every research application or risk-free at any dose